General Information

    • DRAMP ID

    • DRAMP01314

    • Peptide Name

    • Phylloseptin 12 (PS-12; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)

    • Family

    • Not found

    • Gene

    • psn-12

    • Sequence

    • FLSLLPSIVSGAVSLAKKLG

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)C)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium:
        Target OrganismActivity
        Micrococcus luteus ATCC 49732MIC=1.3 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01314.

Physicochemical Information

    • Formula

    • C94H162N22O25

    • Absent Amino Acids

    • CDEHMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 2000.45

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 21.38

    • Hydrophobicity

    • 1.245

    • Aliphatic Index

    • 156

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP01314

Comments Information

    • Function

    • Has antibacterial activity against the Gram-positive bacterium M. luteus. Does not inhibit the growth of the fungus C. albicans.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.

    • Reference

    • Peptides. 2007 Jul;28(7):1331-1343.

    • Author

    • Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.