• • DRAMP ID

  • DRAMP01319

• • Peptide Name

  • Cathelicidin-AL (Gly-rich; Frogs, amphibians, animals)

• • Source

  • Amolops loloensis

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA

• • Sequence Length

  • 48

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)O)C(C)C

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus ATCC25923	MIC=6.25 µg/ml
      Staphylococcus aureus ATCC43300	MIC=6.25 µg/ml
      Bacillus subtilis (MIC=100 µg/ml);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli ML-35P	MIC=25 µg/ml
      Psecdomonas aeruginosa PA01	MIC=12.5 µg/ml
      Psecdomonas aeruginosa ATCC27853	MIC=6.25 µg/ml

    • Yeast:

      Target Organism	Activity
      Candida albicans ATCC2002	MIC=50 µg/ml

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • [Ref.22009138]No cytotoxic against HUVEC or RMMCs at the concentration of 0.4 mg/ml.

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP01319.

DRAMP01319

• • Function

  • Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.

• ·Literature 1

• • Title

  • Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate.

• • Pubmed ID

  • 22009138

• • Reference

  • Amino Acids. 2012 Aug;43(2):677-685.

• • Author

  • Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R.