General Information

    • DRAMP ID

    • DRAMP01393

    • Peptide Name

    • Odorranain-W1 (OdW1; Frogs, amphibians, animals)

    • Source

    • Odorrana grahami (Yunnanfu frog) (Rana grahami)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFGKSSVWGRKYYVDLAGCAKA

    • Sequence Length

    • 23

    • Protein Existence

    • Transcript level

    • SMILES

    • CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.17272268] Gram-negative bacterium:
        Target OrganismActivity
        Escherichia coli (MIC=12.60 μg/ml);-
      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureusMIC=6.30 μg/ml
        Bacillus subtilisMIC=6.30 μg/ml
      • Yeast:
        Target OrganismActivity
        Candida albicansMIC=3.15 μg/ml

    • Hemolytic Activity

      • [Ref.17272268] RCH=17.6 ± 2.2% against rabbit red blood cells. RCH, red cell hemolysis.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • PDB ID

    • Predicted Structure

Physicochemical Information

    • Formula

    • C114H174N30O30S

    • Absent Amino Acids

    • EHIMNPQT

    • Common Amino Acids

    • G

    • Mass

    • 2476.88

    • PI

    • 9.52

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • -13.67

    • Hydrophobicity

    • 0.013

    • Aliphatic Index

    • 72.17

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8480

    • Absorbance 280nm

    • 385.45

    • Polar Residues

    • 9

DRAMP01393

DRAMP01393 chydropathy plot

Comments Information

    • Function

    • Odorranain-W1 has hemolytic activity against rabbit red cell.

Literature Information

  • ·Literature 1

    • Title

    • Anti-infection peptidomics of amphibian skin.

    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.

    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.