General Information

    • DRAMP ID

    • DRAMP01874

    • Peptide Name

    • Brevinin-1Eba (Frogs, amphibians, animals)

    • Source

    • Rana esculenta

    • Family

    • Not found

    • Gene

    • Transcript level

    • Sequence

    • VIPFVASVAAEMMPHVYCAASRKC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C114H182N30O30S4

    • Absent Amino Acids

    • DGLNQTW

    • Common Amino Acids

    • A

    • Mass

    • 2581.12

    • PI

    • 8.03

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 1.49

    • Hydrophobicity

    • 0.863

    • Aliphatic Index

    • 85.42

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 70.22

    • Polar Residues

    • 5

DRAMP01874

DRAMP01874 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.

    • Reference

    • J Biol Chem. 1994 Apr 22;269(16):11956-61.

    • Author

    • Simmaco M, Mignogna G, Barra D, Bossa F.