• • DRAMP ID

  • DRAMP02229

• • Peptide Name

  • Ranatuerin-2 (Frogs, amphibians, animals)

• • Source

  • Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • GLFLDTLKGAAKDVAGKLEGLKCKITGCKLP

• • Sequence Length

  • 31

• • UniProt Entry

  • P82742

• • Protein Existence

  • Protein level

• • SMILES

  • CC[C@@H](C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)O)C(C)C)CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC1=O

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • • [Ref.9784389] Gram-positive bacterium:

      Target Organism	Activity
      Staphylococcus aureus	MIC=60 µM

• • Hemolytic Activity

  • • [Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys23 and Cys28.

• • Stereochemistry

  • L

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP02229.

DRAMP02229

• • Function

  • Antibacterial activity against Gram-positive bacterium S.aureus. Has no detectable hemolytic activity.

• ·Literature 1

• • Title

  • Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana.

• • Pubmed ID

  • 9784389

• • Reference

  • Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592.

• • Author

  • Goraya J, Knoop FC, Conlon JM.