General Information

    • DRAMP ID

    • DRAMP02268

    • Peptide Name

    • Xenopsin precursor fragment (XPF; Frogs, amphibians, animals)

    • Source

    • Xenopus laevis (African clawed frog)

    • Family

    • Belongs to the magainin family

    • Gene

    • Not found

    • Sequence

    • GWASKIGQTLGKIAKVGLKELIQPK

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coliMIC=16-31 µg/ml
        K. PneumonaeMIC=62-125 µg/ml
        Pseudomonas aeruginosa (MIC=125-250 µg/ml);-
      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureusMIC=250-500 µg/ml
        Streptococcus faecalisMIC=250-500 µg/ml
      • Yeast:
        Target OrganismActivity
        Candida albicansMIC=250-500 µg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02268 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02268.

Physicochemical Information

    • Formula

    • C123H211N33O32

    • Absent Amino Acids

    • CDFHMNRY

    • Common Amino Acids

    • K

    • Mass

    • 2664.23

    • PI

    • 10.18

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +4

    • Boman Index

    • -8.34

    • Hydrophobicity

    • -0.116

    • Aliphatic Index

    • 113.2

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 229.17

    • Polar Residues

    • 6

DRAMP02268

DRAMP02268 chydropathy plot

Comments Information

    • Function

    • XPF has antimicrobial activity.

    • Tissue specificity

    • XPF is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa, it is stored as active, processed peptides in large granules within the granular gland secretions of the skin.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides in the stomach of Xenopus laevis.

    • Reference

    • J Biol Chem. 1991 Oct 15;266(29):19851-19857.

    • Author

    • Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M.