General Information

    • DRAMP ID

    • DRAMP02318

    • Peptide Name

    • Grammistin Pp1 (Group II grammistin; fish, chordates, animals)

    • Source

    • Pogonoperca punctata (Clown grouper) (Bearded grouper)

    • Family

    • Belongs to the grammistin family (Group 2 subfamily)

    • Gene

    • Not found

    • Sequence

    • FIGGIISFFKRLF

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria:
        Target OrganismActivity
        Bacillus subtilis IAM 1026MIC=3.13 µg/ml
        Staphylococcus aureus IAM 1011 (MIC=3.13 µg/ml);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Aeromonas salmonicida NCIBM 1102MIC=50 µg/ml
        Escherichia coli JCM 1649MIC>50 µg/ml
        P. dameselae subsp. Piscicida Sp 9587MIC=6.25 µg/ml
        Salmonella typhimurium S1MIC>50 µg/ml
        S. putrefaciens IAM 1509MIC=6.25 µg/ml
        Vibrio anguillarum NCIBM 829MIC=12.5 µg/ml
        Vibrio parahaemolyticusMIC=25 µg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02318 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02318.

Physicochemical Information

    • Formula

    • C79H117N17O15

    • Absent Amino Acids

    • ACDEHMNPQTVWY

    • Common Amino Acids

    • F

    • Mass

    • 1544.9

    • PI

    • 11

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • 9.61

    • Hydrophobicity

    • 1.423

    • Aliphatic Index

    • 120

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP02318

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Interaction of grammistins with lipids and their antibacterial activity.

    • Reference

    • Fish. Sci. 2001 Oct;67:928-933.

    • Author

    • Yokota H, Nagashima Y, Shiomi K.