General Information

    • DRAMP ID

    • DRAMP02362

    • Peptide Name

    • Pleurocidin-like peptide AP3 (NRC-13; fish, chordates, animals; Predicted)

    • Source

    • Hippoglossoides platessoides (American plaice AP3)

    • Family

    • Not found

    • Gene

    • ple

    • Sequence

    • GWRTLLKKAEVKTVGKLALKHYL

    • Sequence Length

    • 23

    • Protein Existence

    • Predicted

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria:
        Target OrganismActivity
        Aeromonas salmonicida 99-1MIC=4 µg/ml
        A. salmonicida 97-4MIC=2 µg/ml
        Salmonella enterica serovar Typhimurium MS7953sMIC=2 µg/ml
        S. enterica serovar Typhimurium 14028sMIC=8 µg/ml
        Pseudomonas aeruginosa K799MIC=4 µg/ml
        Pseudomonas aeruginosa Z61MIC=1 µg/ml
        Escherichia coli CGSC 4908MIC=2 µg/ml
        E. coli UB1005MIC=4 µg/ml
        E. coli DC2MIC=2 µg/ml
      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus epidermidis C621MIC=4 µg/ml
        Staphylococcus aureus (MRSA) C623MIC=4 µg/ml
      • Yeast:
        Target OrganismActivity
        Candida albicans C627MIC=4 µg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02362.

Physicochemical Information

    • Formula

    • C125H210N34O29

    • Absent Amino Acids

    • CDFIMNPQS

    • Common Amino Acids

    • KL

    • Mass

    • 2653.25

    • PI

    • 10.3

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +6

    • Boman Index

    • -18.91

    • Hydrophobicity

    • -0.178

    • Aliphatic Index

    • 118.7

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 317.73

    • Polar Residues

    • 5

DRAMP02362

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Novel antimicrobial peptides derived from flatfish genes.

    • Reference

    • Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.

    • Author

    • Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.