General Information

    • DRAMP ID

    • DRAMP02441

    • Peptide Name

    • Gramicidin S

    • Source

    • Bacillus brevis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VXLFPVXLFP

    • Sequence Length

    • 10

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.29499484] Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureus subsp.aureus CIP 4.83 ATCC 6538MIC=3.125μg/mL
        Bacillus subtilis subsp. subtilis CIP 52.65MIC=3.125μg/ml
        Enterococcus faecalis CIP 103015MIC=3.125μg/ml
        Enterococcus faecalis CIP 103214MIC=3.125μg/ml
        Bacillus cereus CIP 66.24MIC=6.25μg/ml
        Streptococcus salivarius CIP 102503MIC=3.125μg/ml
        Enterococcus faecium CIP 103014 (MIC=3.125μg/ml);-
      • Gram-negative bacterium:
        Target OrganismActivity
        Escherichia coli CIP 53.126 ATCC 8739MIC=12.5μg/ml
        Pseudomonas aeruginosa CIP 82.118 ATCC 9027MIC>=100μg/ml

    • Hemolytic Activity

      • [Ref.29499484] It has 74% hemolysis at 50μg/ml, 83% hemolysis at 100μg/ml against human red blood cells.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • No specific N-terminal

    • C-terminal Modification

    • No specific C-terminal

    • Nonterminal Modifications and Unusual Amino Acids

    • The 'O' in sequence is Ornithine

    • Stereochemistry

    • Mixed(D-Phe)

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C50H70N8O7

    • Absent Amino Acids

    • ACDEGHIKMNQRSTWY

    • Common Amino Acids

    • FLPVX

    • Mass

    • 1153.85

    • PI

    • 5.49

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • 23.88

    • Hydrophobicity

    • 1.84

    • Aliphatic Index

    • 136

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP02441

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • β,γ-diamino acids as building blocks for new analogues of Gramicidin S: Synthesis and biological activity

    • Reference

    • Eur J Med Chem. 2018 Apr 10;149:122-128.

    • Author

    • Wan Y, Stanovych A, Gori D, Zirah S, Kouklovsky C, Alezra V.