General Information
-
DRAMP ID
- DRAMP03524
-
Peptide Name
- Lebocin-like anionic peptide 1 (Insects, animals)
-
Source
- Galleria mellonella (Greater wax moth)
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Family
- Not found
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Gene
- Not found
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Sequence
- EADEPLWLYKGDNIERAPTTADHPILPSIIDDVKLDPNRRYA
-
Sequence Length
- 42
-
UniProt Entry
- P85211
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Protein Existence
- Protein level
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SMILES
- CC[C@@H](C)[C@H](NC(=O)CC[C@H](NC(=O)[C@H](C)NC(=O)CC[C@H](N)C(=O)N[C@@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)[C@H](C)CC)[C@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
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Target Organism
-
- Gram-positive bacteria:
Target Organism Activity Micrococcus luteus MIC=22.7 µM Listeria monocytogenes MIC=90.9 µM - Fungi:
Target Organism Activity Aspergillus niger MIC=90.9 µM Trichoderma harzianum MIC=90.9 µM
- Gram-positive bacteria:
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
Physicochemical Information
-
Formula
- C215H334N58O68
Absent Amino Acids
- CFMQ
Common Amino Acids
- D
Mass
- 4819.36
PI
- 4.51
Basic Residues
- 6
Acidic Residues
- 9
Hydrophobic Residues
- 14
Net Charge
- -3
-
Boman Index
- -101.46
Hydrophobicity
- -0.774
Aliphatic Index
- 90.71
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8480
Absorbance 280nm
- 206.83
Polar Residues
- 8
DRAMP03524
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Purification and characterization of eight peptides from Galleria mellonella immune hemolymph.
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Pubmed ID
- 17194500
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Reference
- Peptides. 2007;28:533-546.
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Author
- Cytrynska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T.
