General Information
-
DRAMP ID
- DRAMP03829
-
Peptide Name
- GLK-19
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GLKKLLGKLLKKLGKLLLK
-
Sequence Length
- 19
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
-
SMILES
- CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-, Anticancer
-
Target Organism
-
- Gram-negative bacterium:
Target Organism Activity Escherichia coli K12 MIC=10 µM
- Gram-negative bacterium:
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
Physicochemical Information
-
Formula
- C102H194N26O20
Absent Amino Acids
- ACDEFHIMNPQRSTVWY
Common Amino Acids
- L
Mass
- 2104.82
PI
- 10.78
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +7
-
Boman Index
- 8.25
Hydrophobicity
- 0.3
Aliphatic Index
- 184.74
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP03829
Comments Information
Function
- GLK-19 showed a higher activity against Escherichia coli than human LL-37.
Literature Information
- ·Literature 1
-
Title
- APD2: the updated antimicrobial peptide database and its application in peptide design.
-
Pubmed ID
- 18957441
-
Reference
- Nucleic Acids Res. 2009 Jan;37(Database issue):D933-937.
-
Author
- Wang G, Li X, Wang Z.
