General Information

    • DRAMP ID

    • DRAMP18246

    • Peptide Name

    • Thuricin 439A,439B(Bacteriocin)

    • Source

    • Bacillus thuringiensis strain B439

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GWVAXVGAXGTAALASGGV

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive (Narrow)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Based on its unique physical and biological characteristics we can conclude that thuricin 439 is a novel bacteriocin.

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C64H98N18O18

    • Absent Amino Acids

    • CDEFHIKMNPQRY

    • Common Amino Acids

    • AG

    • Mass

    • 1666.28

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • 0

    • Boman Index

    • 2715

    • Hydrophobicity

    • 1.105

    • Aliphatic Index

    • 92.63

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 305.56

    • Polar Residues

    • 7

DRAMP18246

Comments Information

    • The two active peptides are likely to be encoded by a single gene, whose product may undergo one or more post translational modifications that result in two active products of different molecular masses.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and characterisation of a novel bacteriocin produced by Bacillus thuringiensis strain B439.

    • Reference

    • FEMS Microbiol Lett. 2003 Mar 14;220(1):127-31.

    • Author

    • Ahern M, Verschueren S, van Sinderen D.