General Information

    • DRAMP ID

    • DRAMP18395

    • Peptide Name

    • moroPC-NH2 (moronecidin-like peptide; fish, animals)

    • Source

    • Parachaenichthys charcoti

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FFGHLFRGIINVGKHIHGLLSG

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(N)=O)[C@H](C)CC)C(C)C)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • Active against Gram- E. cloacae ATCC 13047 (MIC 25 uM), S. sonnei (ATCC 29930) (MIC 5 uM), Psychrobacter sp. (PAMC 25501) (MIC 2.5 uM), E. coli DH5alpha (MIC 5 uM), Gram+ E. faecalis (ATCC 29212) (MIC 25 uM), S. pyogenes (ATCC 19615) (MIC 2.5 uM), S. aureus (ATCC 33591), L. monocytogenes (ATCC 15313) (MIC 5 uM), and yeast C. tropicalis (ATCC 20115) (MIC 5 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP18395.

Physicochemical Information

    • Formula

    • C115H175N33O25

    • Absent Amino Acids

    • ACDEMPQTWY

    • Common Amino Acids

    • G

    • Mass

    • 2419.86

    • PI

    • 11

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +5

    • Boman Index

    • 271

    • Hydrophobicity

    • 0.6

    • Aliphatic Index

    • 119.55

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP18395

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Characterization of Two Antimicrobial Peptides from Antarctic Fishes (Notothenia coriiceps and Parachaenichthys charcoti)

    • Reference

    • PLoS One. 2017 Jan 25;12(1):e0170821.

    • Author

    • Shin SC, Ahn IH, Ahn DH, Lee YM, Lee J, Lee JH, Kim HW, Park H