• • DRAMP ID

  • DRAMP20936

• • Peptide Name

  • ΔPb-CATH1

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • RVKRFKKFFRKIKKGFRKIFKKTKIFIG

• • Sequence Length

  • 28

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@H](C)CC)[C@H](C)CC)[C@@H](C)O)[C@H](C)CC)C(=O)NCC(=O)O

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.28630199] Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus (ATCC 29213)(MIC>128 μg/ml); B. cereus ATCC 10876 (MIC=46 μg/ml);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli ATCC 25922	MIC=2 μg/ml
      Pseudomonas aeruginosa ATCC 27853	MIC=3 μg/ml
      S. typhimurium ATCC 14028	MIC=1.5 μg/ml

• • Hemolytic Activity

  • • [Ref.28630199]1.4 ± 0.4% hemolysis at 8 μg/ml, 5.1 ± 0.5% hemolysis at 16 μg/ml, 7.3 ± 0.6% hemolysis at 32 μg/ml, 12.2 ± 0.7% hemolysis at 64 μg/ml against chicken red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP20936_predicted_structure.pdb to download.

DRAMP20936

• • Function

  • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.

• ·Literature 1

• • Title

  • Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity

• • Pubmed ID

  • 28630199

• • Reference

  • Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00530-17.

• • Author

  • Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C.