General Information

    • DRAMP ID

    • DRAMP29244

    • Peptide Name

    • Peptide 6(lactoferrin 552-563)

    • Source

    • Synthetic construct

    • Family

    • Belongs to the transferrin family

    • Gene

    • LTF

    • Sequence

    • TNGESTADWAKN

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

    • SMILES

    • C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N[C@H](C(=O)N[C@@H](CC(=O)N[C@@H](CCCCN)C(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial,Antiviral

    • Target Organism

      • [Ref.28878220]Virus:
        Target OrganismActivity
        A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells(EC50=400 ±0.02 pM);-
      • A/Parma/24/09 H1N1:
        Target OrganismActivity
        inhibition of virus replication in MDCK cells(EC50=50.000 ± 230 pM);-
      • A/Parma0/5/06 H3N2:
        Target OrganismActivity
        inhibition of virus replication in MDCK cellsEC50=10.000± 120 pM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • hemagglutinin (HA)

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Predicted Structure

    • There is no predicted structure for DRAMP29244.

Physicochemical Information

    • Formula

    • C53H80N16O22

    • Absent Amino Acids

    • CFHILMPQRVY

    • Common Amino Acids

    • ANT

    • Mass

    • 1293.31

    • PI

    • 4.37

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 3

    • Net Charge

    • -1

    • Boman Index

    • -3601

    • Hydrophobicity

    • -1.483

    • Aliphatic Index

    • 16.67

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 500

    • Polar Residues

    • 6

DRAMP29244

Comments Information

    • Function

    • Antiviral activity against Influenza virus.

Literature Information

  • ·Literature 1

    • Title

    • Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors.

    • Reference

    • Sci Rep. 2017 Sep 6;7(1):10593.

    • Author

    • Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P.