• • DRAMP ID

  • DRAMP30312

• • Peptide Name

  • Ranatuerin-2P (Ranatuerin 2P; Frogs, amphibians, animals)

• • Source

  • Rana pipiens (Northern leopard frog)

• • Family

  • Iridoviridae, Herpesviridae

• • Gene

  • Not found

• • Sequence

  • GLMDTVKNVAKNLAGHMLDKLKCKITGC

• • Sequence Length

  • 28

• • UniProt Entry

  • Q8QFQ4##P82847

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antiviral

• • Target Organism

  • • [Ref.11601906]Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(90% inhibition at 500 µM);
    • Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(99% inhibition at 50 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization of a C-terminal Cys residue (forming a disulfide bond)

• • Nonterminal Modifications and Unusual Amino Acids

  • There is a disulfide bond between Cys22 and Cys27.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 2K10

• Predicted Structure

• There is no predicted structure for DRAMP30312.

DRAMP30312

• • Comment

  • No comments found on DRAMP database

• ·Literature 1

• • Title

  • Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.

• • Pubmed ID

  • 11601906

• • Reference

  • Virology. 2001 Sep 30;288(2):351-7.

• • Author

  • Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.