General Information

    • DRAMP ID

    • DRAMP30313

    • Peptide Name

    • Esculentin-2P (Frogs, amphibians, animals)

    • Source

    • Rana pipiens (northern leopard frog)

    • Family

    • Iridoviridae, Herpesviridae

    • Gene

    • Not found

    • Sequence

    • GFLSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC

    • Sequence Length

    • 37

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.11601906]
      • Frog Virus 3: inhibition of FV3 infection in fathead minnow(FHM) cells(90% inhibition at 500 µM);
      • Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells( 90% inhibition at 50 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization of a C-terminal Cys residue (forming a disulfide bond)

    • Nonterminal Modifications and Unusual Amino Acids

    • There is a disulfide bond between Cys31 and Cys37.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP30313 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP30313.

Physicochemical Information

    • Formula

    • C176H296N50O45S2

    • Absent Amino Acids

    • EHMPTWY

    • Common Amino Acids

    • GKL

    • Mass

    • 3896.71

    • PI

    • 10.21

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 17

    • Net Charge

    • +6

    • Boman Index

    • -1869

    • Hydrophobicity

    • 0.481

    • Aliphatic Index

    • 108.11

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.47

    • Polar Residues

    • 11

DRAMP30313

DRAMP30313 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.

    • Reference

    • Virology. 2001 Sep 30;288(2):351-7.

    • Author

    • Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.