General Information

    • DRAMP ID

    • DRAMP31553

    • Peptide Name

    • RJ2-Y2,9,16

    • Source

    • Synthetic construct

    • Family

    • Herpesviridae

    • Gene

    • Not found

    • Sequence

    • KYAKKAAKYAKKAAKYAKKAA

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.16923027]Herpes simplex virus 1(HSV-1): inhibition of viral entry into Vero cells(IC50=146 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.16923027]No cytotoxicity against Human fibroblasts MRC-5 cells up to 448 µM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31553 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP31553.

Physicochemical Information

    • Formula

    • C108H182N30O25

    • Absent Amino Acids

    • CDEFGHILMNPQRSTVW

    • Common Amino Acids

    • AK

    • Mass

    • 2300.82

    • PI

    • 10.3

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +9

    • Boman Index

    • -3408

    • Hydrophobicity

    • -1.086

    • Aliphatic Index

    • 42.86

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 4470

    • Absorbance 280nm

    • 223.5

    • Polar Residues

    • 3

DRAMP31553

DRAMP31553 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Prediction of activity, synthesis and biological testing of anti-HSV active peptides. 

    • Reference

    • Chem Biol Drug Des. 2006 Jul;68(1):58-66.

    • Author

    • Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T.