General Information

    • DRAMP ID

    • DRAMP31554

    • Peptide Name

    • RJ2-A1,4,8; K3,6,7,9,13; W5,11,17

    • Source

    • Synthetic construct

    • Family

    • Herpesviridae

    • Gene

    • Not found

    • Sequence

    • AAKAWKKAKAWKKAKWWKKAA

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.16923027]Herpes simplex virus 1(HSV-1): inhibition of viral entry into Vero cells(IC50=238 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.16923027]No cytotoxicity against Human fibroblasts MRC-5 cells up to 448 µM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31554 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP31554.

Physicochemical Information

    • Formula

    • C122H190N34O22

    • Absent Amino Acids

    • CDEFGHILMNPQRSTVY

    • Common Amino Acids

    • K

    • Mass

    • 2485.07

    • PI

    • 10.9

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +9

    • Boman Index

    • -2615

    • Hydrophobicity

    • -1.157

    • Aliphatic Index

    • 38.1

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 22000

    • Absorbance 280nm

    • 1100

    • Polar Residues

    • 0

DRAMP31554

DRAMP31554 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Prediction of activity, synthesis and biological testing of anti-HSV active peptides. 

    • Reference

    • Chem Biol Drug Des. 2006 Jul;68(1):58-66.

    • Author

    • Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T.