General Information

    • DRAMP ID

    • DRAMP31557

    • Peptide Name

    • CHR-5, Env GP (643-678)

    • Source

    • Synthetic construct

    • Family

    • Retroviridae

    • Gene

    • Not found

    • Sequence

    • HSLIEESQNQQEKNEQELLELDKWASLWNWFNITNW

    • Sequence Length

    • 36

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.17276993]human immunodeficiency virus (HIV): inhibition of cell-cell fusion in MT-2 cells(IC50=2,185.00 ± 15.00 nM; IC90=2,858.00 ± 6.00 nM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31557 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP31557.

Physicochemical Information

    • Formula

    • C203H295N53O64

    • Absent Amino Acids

    • CGMPRVY

    • Common Amino Acids

    • E

    • Mass

    • 4501.89

    • PI

    • 4.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 13

    • Net Charge

    • -4

    • Boman Index

    • -8492

    • Hydrophobicity

    • -1.142

    • Aliphatic Index

    • 78.61

    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 22000

    • Absorbance 280nm

    • 628.57

    • Polar Residues

    • 9

DRAMP31557

DRAMP31557 chydropathy plot

Comments Information

    • Mechanism

    • CHR-5 can bind to LUVs of POPC

Literature Information

  • ·Literature 1

    • Title

    • HIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides

    • Reference

    • J Biol Chem. 2007 Mar 30;282(13):9612-9620.

    • Author

    • Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S.