General Information

    • DRAMP ID

    • DRAMP31558

    • Peptide Name

    • SARS-CoV S (668–679), SP-10

    • Source

    • Synthetic construct

    • Family

    • Coronaviridae

    • Gene

    • Not found

    • Sequence

    • STSQKAnti-SIVAYTM

    • Sequence Length

    • 12

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.16337697]SARS-CoV: Inhibition of pseudovirus infection in Vero cells(IC50=1.88 ± 0.52 nM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • ACE2

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31558 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP31558.

Physicochemical Information

    • Formula

    • C56H94N14O20S

    • Absent Amino Acids

    • CDEFGHLNPRW

    • Common Amino Acids

    • S

    • Mass

    • 1315.5

    • PI

    • 8.31

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +1

    • Boman Index

    • -1345

    • Hydrophobicity

    • -0.008

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 6

DRAMP31558

Comments Information

    • Mechanism

    • block the binding of S protein to ACE2.

Literature Information

  • ·Literature 1

    • Title

    • Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction.

    • Reference

    • Antiviral Res. 2006 Feb;69(2):70-6.

    • Author

    • Ho TY, Wu SL, Chen JC, Wei YC, Cheng SE, Chang YH, Liu HJ, Hsiang CY.