General Information

    • DRAMP ID

    • DRAMP31561

    • Peptide Name

    • LEDGF/p75 (355-377)

    • Source

    • Synthetic construct

    • Family

    • Retroviridae

    • Gene

    • Not found

    • Sequence

    • IHAEIKNSLKIDNLDVNRCIEAL

    • Sequence Length

    • 23

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.18331842]Human immunodeficiency virus (HIV): Inhibition of integrase activity (3' end processing)(IC50=165±28 µM); inhibition of integrase activity(strand transfer)(IC50=153±28 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • Integrase

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31561 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP31561.

Physicochemical Information

    • Formula

    • C113H193N33O36S

    • Absent Amino Acids

    • FGMPQTWY

    • Common Amino Acids

    • I

    • Mass

    • 2622.03

    • PI

    • 5.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 10

    • Net Charge

    • 0

    • Boman Index

    • -4168

    • Hydrophobicity

    • -0.048

    • Aliphatic Index

    • 140

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP31561

DRAMP31561 chydropathy plot

Comments Information

    • Mechanism

    • The LEDGF/p75 peptide modestly inhibited IN catalysis and was dependent on IN–DNA assembly. The peptide was also effective at disrupting LEDGF/p75–IN complex formation.

Literature Information

  • ·Literature 1

    • Title

    • Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.

    • Reference

    • FEBS Lett. 2008 Apr 30;582(10):1425-30.

    • Author

    • Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N.