General Information

    • DRAMP ID

    • DRAMP32368

    • Peptide Name

    • CPe-III(CPe-III-S)

    • Source

    • Chickpea (Cicer arietinum L.)

    • Family

    • Gene

    • Not found

    • Sequence

    • RQSHFANAQP

    • Sequence Length

    • 10

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells:
        Target OrganismActivity
        MDA-MB-231 (EC50=1.50 μmol/mL); MCF-7EC50=2.38 μmol/mL

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • p53 protein

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP32368 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP32368.

Physicochemical Information

    • Formula

    • C49H74N18O15

    • Absent Amino Acids

    • CDEGIKLMTVWY

    • Common Amino Acids

    • AQ

    • Mass

    • 131595

    • PI

    • 10.55

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -3410

    • Hydrophobicity

    • -1.42

    • Aliphatic Index

    • 20

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP32368

Comments Information

    • the bioactive peptide combined the DNA binding domain of p53 protein by hydrogen bonds, induced the expression of p53 protein and facilitated its stability so that it inhibited the cell proliferation.

Literature Information

  • ·Literature 1

    • Title

    • Antioxidant activity and anti-proliferative effect of a bioactive peptide from chickpea (Cicer arietinum L.)

    • Reference

    • Author