• • DRAMP ID

  • DRAMP32372

• • Peptide Name

  • Brevilaterin B

• • Source

  • Brevibacillus laterosporus

• • Family

• • Gene

  • Not found

• • Sequence

  • XXMXIVVKVLKYLX

• • Sequence Length

  • 14

• • UniProt Entry

  • Notavailable

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Anticancer

• • Target Organism

  • • Tumor cells:

      Target Organism

      Activity

      HT-29 (IC50=1.40±0.09 µg/mL); SW1990 (IC50=13.40±0.08 µg/mL); SMMC-7721 (IC50=13.81±0.31 µg/mL); SW480 (IC50=17.15±0.97 µg/mL); EC109 (IC50=2.13±0.23 µg/mL); A498 (IC50=2.33±0.49 µg/mL); DU145 (IC50=2.56±0.23 µg/mL); HeLa (IC50=2.60±0.24 µg/mL); A431 (IC50=2.75±0.07 µg/mL); PANC-1 (IC50=3.11±0.49 µg/mL); KB (IC50=3.14±0.07 µg/mL); HeLa S3 (IC50=3.16±0.45 µg/mL); EC9706 (IC50=3.23±0.16 µg/mL); A-375 (IC50=4.16±0.15 µg/mL); MDA-MB-231 (IC50=4.16±0.27 µg/mL); SK-OV-3 (IC50=4.26±0.25 µg/mL); MCF-7 (IC50=4.94±0.28 µg/mL); A549 (IC50=5.54±0.55 µg/mL); BGC-823 (IC50=5.68±0.25 µg/mL); SGC-7901 (IC50=5.73±0.21 µg/mL); Tca8113 (IC50=5.82±0.25 µg/mL); K562 (IC50=5.86±0.66 µg/mL); PC-3M (IC50=6.17±0.24 µg/mL); A2780 (IC50=7.40±0.36 µg/mL); HCT 116 (IC50=7.67±0.57 µg/mL); Hep-G2

      IC50=9.84±0.39 µg/mL

• • Hemolytic Activity

  • • Not available

• • Cytotoxicity

  • • Human Splenic Fibroblasts (HSF): IC50=12.78±0.33 µg/mL; Endometrial epithelial cells(HEEC): IC50=2.66±0.34 µg/mL; HPDE6c7 Human Pancreatic Duct Epithelial Cell: IC50=3.45±0.20 µg/mL; Normal Human Hepatic Cell (Lo-2): IC50=2.91±0.07 µg/mL; NCM460: IC50=3.04±0.10 µg/mL; CCD-19Lu: IC50=4.76±0.03 µg/mL; Human Intrahepatic Biliary Epithelial Cells (HIBEpiC): IC50=2.37±0.38 µg/; HEK293: IC50=4.78±0.32 µg/mL; IOSE80: IC50=1.12±0.04 µg/mL; RWPE-1: IC50=1.07±0.34 µg/mL; GES-1: IC50=10.62±0.73 µg/mL; MCF-10A: IC50=1.58±0.33 µg/mL;

• • Binding Target

  • Not available

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • X(1)=Hmp=2-hydroxy-3-methylpentanoic acid; X(2)=Aba=2-amino-2-butenoic acid; X(4)=Ornithine; X(14)=valinol

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • Notavailable

• Predicted Structure

• There is no predicted structure for DRAMP32372.

DRAMP32372

• • Not available

• ·Literature 1

• • Title

  • Brevilaterin B from Brevibacillus laterosporus has selective antitumor activity and induces apoptosis in epidermal cancer

• • Pubmed ID

  • Not available

• • Reference

• • Author