General Information

    • DRAMP ID

    • DRAMP32374

    • Peptide Name

    • Hepcidin TH1-5

    • Source

    • Skin Secretion of the African Frog, Kassina senegalensis

    • Family

    • Gene

    • Not found

    • Sequence

    • GIKCRFCCGCCTPGICGVCCRF

    • Sequence Length

    • 22

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells:
        Target OrganismActivity
        MCF-7IC50=20 μg/mL

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP32374 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP32374.

Physicochemical Information

    • Formula

    • C94H153N29O24S8

    • Absent Amino Acids

    • ADEHLMNQSWY

    • Common Amino Acids

    • C

    • Mass

    • 270469

    • PI

    • 8.21

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +3

    • Boman Index

    • -412

    • Hydrophobicity

    • 1

    • Aliphatic Index

    • 48.64

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 500

    • Absorbance 280nm

    • 23.81

    • Polar Residues

    • 13

DRAMP32374

DRAMP32374 chydropathy plot

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Hepcidin TH1-5 Induces Apoptosis and Activate Caspase-9 in MCF-7 Cells

    • Reference

    • Author