General Information

    • DRAMP ID

    • DRAMP32381

    • Peptide Name

    • DN4

    • Source

    • Synthetic

    • Family

    • Gene

    • Not found

    • Sequence

    • ILGKIWKGIVSDF

    • Sequence Length

    • 13

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells:
        Target OrganismActivity
        Hep-G2IC50=191.67±12.02 µg/mL

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Vero: IC50>256 µg/mL; THLE-3: IC50>256 µg/mL

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP32381 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP32381.

Physicochemical Information

    • Formula

    • C72H114N16O17

    • Absent Amino Acids

    • ACEHMNPQRTY

    • Common Amino Acids

    • I

    • Mass

    • 169003

    • PI

    • 9.54

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 769

    • Hydrophobicity

    • 0.808

    • Aliphatic Index

    • 142.31

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 3

DRAMP32381

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways

    • Reference

    • Author