General Information

    • DRAMP ID

    • DRAMP32388

    • Peptide Name

    • Lycosin-II

    • Source

    • Synthetic

    • Family

    • Gene

    • Not found

    • Sequence

    • VWLSALKFIGKHLAKHQLSKL

    • Sequence Length

    • 21

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells:
        Target OrganismActivity
        HCT 116IC50=70.79 µg/mL

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • IC50 on PBMCs was = 92.0 ± 39.6 μM

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP32388 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP32388.

Physicochemical Information

    • Formula

    • C116H189N31O25

    • Absent Amino Acids

    • CDEMNPRTY

    • Common Amino Acids

    • L

    • Mass

    • 277491

    • PI

    • 11.28

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +6

    • Boman Index

    • -43

    • Hydrophobicity

    • 0.271

    • Aliphatic Index

    • 134.76

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 275

    • Polar Residues

    • 3

DRAMP32388

DRAMP32388 chydropathy plot

Comments Information

    • Lycosin-II Suppresses the Growth of Tumor Cells and Kills them Through Membrane Disruption and Apoptosis Induction

Literature Information

  • ·Literature 1

    • Title

    • Lycosin-II Suppresses the Growth of Tumor Cells and Kills them Through Membrane Disruption and Apoptosis Induction

    • Reference

    • Author