General Information

    • DRAMP ID

    • DRAMP32446

    • Peptide Name

    • Ⅱ

    • Source

    • Peptaibols

    • Family

    • Gene

    • Not found

    • Sequence

    • XPAXXFXPAXXLXXLXXLX

    • Sequence Length

    • 19

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells:
        Target OrganismActivity
        BEL-7402 (IC50=1.98 μM); BGC-823 (IC50=2.11 μM); A549 (IC50=2.30 μM); A2780 (IC50>10 μM); HCT 8IC50>10 μM

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Aminoethanol

    • Nonterminal Modifications and Unusual Amino Acids

    • X(1/4/5/17)=Aib=1-amino-isobutyric acid; X(7/13/16)=Iva=Isovaline; X(10)=AHMA=3-amino-2-hydroxy-3-methylbutanoic acid; X(11/14/19)(β)A=β-Alanine

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP32446 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP32446.

Physicochemical Information

    • Formula

    • C43H46N8O-2

    • Absent Amino Acids

    • CDEGHIKMNQRSTVWY

    • Common Amino Acids

    • X

    • Mass

    • 217413

    • PI

    • 6.11

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • 2136

    • Hydrophobicity

    • 0.768

    • Aliphatic Index

    • 72.11

    • Half Life

      • Mammalian:/
      • Yeast:/
      • E.coli:/

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP32446

DRAMP32446 chydropathy plot

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Not available

    • Reference

    • Author