General Information

    • DRAMP ID

    • DRAMP32450

    • Peptide Name

    • B8

    • Source

    • Hedyotis biflora

    • Family

    • Gene

    • Not found

    • Sequence

    • GIPCGESCAFLPCLTSLLGCTCQNKVCYRD

    • Sequence Length

    • 30

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells:
        Target OrganismActivity
        MOH-1 (IC50=1.88 μM); PANC-1 (IC50=1.95 μM); Capan-2 (IC50=2.14 μM); BxPC-3IC50=3.11 μM

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP32450 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP32450.

Physicochemical Information

    • Formula

    • C134H216N36O42S6

    • Absent Amino Acids

    • HMW

    • Common Amino Acids

    • C

    • Mass

    • 371324

    • PI

    • 6.03

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • 0

    • Boman Index

    • -1633

    • Hydrophobicity

    • 0.413

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 64.31

    • Polar Residues

    • 15

DRAMP32450

DRAMP32450 chydropathy plot

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo

    • Reference

    • Author