• • DRAMP ID

  • DRAMP32460

• • Peptide Name

  • HYL-6

• • Source

  • AMP

• • Family

• • Gene

  • Not found

• • Sequence

  • GIMSSAMKKLAAHIAK

• • Sequence Length

  • 16

• • UniProt Entry

  • Notavailable

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(N)=O)[C@H](C)CC

• • Biological Activity

  • Antimicrobial, Anticancer

• • Target Organism

  • • Tumor cells:

      Target Organism	Activity
      A549 (IC50 ＞50 µmol/L); HCT 116 (IC50 ＞50 µmol/L); Hep-G2	IC50 ＞50 µmol/L

• • Hemolytic Activity

  • • Not available

• • Cytotoxicity

  • • Human Splenic Fibroblasts (HSF): IC50=12.78±0.33 µg/mL; Endometrial epithelial cells(HEEC): IC50=2.66±0.34 µg/mL; HPDE6c7 Human Pancreatic Duct Epithelial Cell: IC50=3.45±0.20 µg/mL; Normal Human Hepatic Cell (Lo-2): IC50=2.91±0.07 µg/mL; NCM460: IC50=3.04±0.10 µg/mL; CCD-19Lu: IC50=4.76±0.03 µg/mL

• • Binding Target

  • Not available

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

  • Notavailable

• Predicted Structure

• There is no predicted structure for DRAMP32460.

DRAMP32460

• • Not available

• ·Literature 1

• • Title

  • Structural modification and antitumor activity of antimicrobial peptide HYL

• • Pubmed ID

  • Not available

• • Reference

• • Author