General Information

    • DRAMP ID

    • DRAMP35964

    • Peptide Name

    • MGS4_V10 (tetramer)

    • Source

    • Synthetic (derived from MGS4)

    • Family

    • Gene

    • Not found

    • Sequence

    • FHAVPQSFYT

    • Sequence Length

    • 10

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: H1993 (EC50=1.5nM); H1299 (EC50=2.5nM); H2009 (EC50=3.4nM); H358 (EC50=3.5nM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Tetramer

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP35964 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35964.

Physicochemical Information

    • Formula

    • C58H77N13O15

    • Absent Amino Acids

    • CDEGIKLMNRW

    • Common Amino Acids

    • F

    • Mass

    • 135703

    • PI

    • 7.54

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +1

    • Boman Index

    • -450

    • Hydrophobicity

    • 0.05

    • Aliphatic Index

    • 39

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 165.56

    • Polar Residues

    • 3

DRAMP35964

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin

    • Reference

    • Commun Biol. 2023 Jan 17;6(1):62.

    • Author

    • Allred CA, Gormley C, Venugopal I, Li S, McGuire MJ, Brown KC.