General Information

    • DRAMP ID

    • DRAMP35967

    • Peptide Name

    • ALA-A2

    • Source

    • Synthetic

    • Family

    • Gene

    • Not found

    • Sequence

    • KLWCKSSQVPQSR

    • Sequence Length

    • 13

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: HT-29 (55.3 ± 2.7% cell viability=200µM); A549  (59.7 ± 1.1% cell viability=200µM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP35967 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35967.

Physicochemical Information

    • Formula

    • C67H111N21O19S

    • Absent Amino Acids

    • ADEFGHIMNTY

    • Common Amino Acids

    • S

    • Mass

    • 176102

    • PI

    • 10.79

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +3

    • Boman Index

    • -3473

    • Hydrophobicity

    • -1.054

    • Aliphatic Index

    • 52.31

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 4

DRAMP35967

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • ALA-A2 Is a Novel Anticancer Peptide Inspired by Alpha-Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation

    • Reference

    • Glob Chall. 2023 Jan 12;7(3):2200213.

    • Author

    • Lerksuthirat T, On-Yam P, Chitphuk S, Stitchantrakul W, Newburg DS, Morrow AL, Hongeng S, Chiangjong W, Chutipongtanate S