General Information

    • DRAMP ID

    • DRAMP35968

    • Peptide Name

    • B1AW

    • Source

    • Skin secretions of the Wuyi torrent frog, Amolops wuyiensis (A. wuyiensisi)

    • Family

    • Gene

    • Not found

    • Sequence

    • FLPLLAGLAANFLPQIICKIARKC

    • Sequence Length

    • 24

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: H838 (IC50=32.15µM); PC-3 (IC50=33.46µM); U251MG (IC50=33.56µM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • HMEC-1: IC50=32.96μM; HaCaT: IC50=44.09μM

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP35968 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35968.

Physicochemical Information

    • Formula

    • C123H205N31O27S2

    • Absent Amino Acids

    • DEHMSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 302476

    • PI

    • 9.76

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • 1786

    • Hydrophobicity

    • 1.142

    • Aliphatic Index

    • 146.67

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 4

DRAMP35968

DRAMP35968 chydropathy plot

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue

    • Reference

    • Comput Struct Biotechnol J. 2023 May 6;21:2960-2972.

    • Author

    • Qin H, Zuo W, Ge L, Siu SWI, Wang L, Chen X, Ma C, Chen T, Zhou M, Cao Z, Kwok HF.