General Information

    • DRAMP ID

    • DRAMP35969

    • Peptide Name

    • B1AW-K

    • Source

    • Synthetic (derived from B1AW)

    • Family

    • Gene

    • Not found

    • Sequence

    • FLPLLAGLAANFLPKIICKIARKC

    • Sequence Length

    • 24

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: U251MG (IC50=3.86µM); PC-3 (IC50=4.283µM); H838 (IC50=5.15µM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • HMEC-1: IC50=26.45μM; HaCaT: IC50=20.53μM

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP35969 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35969.

Physicochemical Information

    • Formula

    • C124H209N31O26S2

    • Absent Amino Acids

    • DEHMQSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 302480

    • PI

    • 10.51

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +4

    • Boman Index

    • 1785

    • Hydrophobicity

    • 1.125

    • Aliphatic Index

    • 146.67

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 4

DRAMP35969

DRAMP35969 chydropathy plot

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue

    • Reference

    • Comput Struct Biotechnol J. 2023 May 6;21:2960-2973.

    • Author

    • Qin H, Zuo W, Ge L, Siu SWI, Wang L, Chen X, Ma C, Chen T, Zhou M, Cao Z, Kwok HF.