General Information

    • DRAMP ID

    • DRAMP35972

    • Peptide Name

    • PMAP-NC

    • Source

    • Synthetic (derived from PMAP-23)

    • Family

    • Gene

    • Not found

    • Sequence

    • RIIDRLWLVRRPOKPKFVLVWVL

    • Sequence Length

    • 23

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: MDA361 (IC50=6.4µM); A549 (IC50=7.1µM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP35972 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35972.

Physicochemical Information

    • Formula

    • C137H222N38O24

    • Absent Amino Acids

    • ACEGHMNQSTY

    • Common Amino Acids

    • LRV

    • Mass

    • 317810

    • PI

    • 12.52

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +5

    • Boman Index

    • -2618

    • Hydrophobicity

    • 0.413

    • Aliphatic Index

    • 152.17

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 500

    • Polar Residues

    • 0

DRAMP35972

DRAMP35972 chydropathy plot

Comments Information

    • A unique structure with an amphipathic N-helix, a central hinge, and a hydrophobic C-helix is responsible for bactericidal and anticancer activity of PMAP-NC. 

Literature Information

  • ·Literature 1

    • Title

    • Rationally designed PMAP-23 derivatives with enhanced bactericidal and anticancer activity based on the molecular mechanism of peptide-membrane interactions

    • Reference

    • Amino Acids. 2023 Aug;55(8):1013-1022.

    • Author

    • Lee H, Shin SH, Yang S.