• • DRAMP ID

  • DRAMP38960

• • Peptide Name

  • Dermaseptin-S4(1-16)

• • Source

  • Phyllomedusa sauvagei (Sauvage's leaf frog)

• • Family

  • Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.

• • Gene

  • Not found

• • Sequence

  • ALWMTLLKKVLKAAAK

• • Sequence Length

  • 16

• • UniProt Entry

  • P80280(1-16)

• • Protein Existence

  • protein level

• • SMILES

  • Not available

• • Biological Activity

  • Antimicrobial,Antibacterial，Anti-Gram-,Antiprotozoal

• • Target Organism

  • • [Ref.10952593] protozoon: P. falciparum-infected RBC(10μM<IC50<50μM);ring stage of P. falciparum(IC50~2.0μM)
    • Gram-negative bacteria:

      Target Organism	Activity
      E. coli	10μM<IC50<50μM

• • Hemolytic Activity

  • • [Ref.10952593]10μM

• • Cytotoxicity

  • • Not found

• • Binding Target

  • plasma membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Not found

• • Stereochemistry

  • L

• • Structure

• • Structure Description

• • PDB ID

  • 2DCX resolved 2DD6 resolved

• Predicted Structure

• Please click DRAMP38960_predicted_structure.pdb to download.

DRAMP38960

• ·Literature 1

• • Title

  • Antimalarial activities of dermaseptin S4 derivatives.

• • Pubmed ID

  • 10952593

• • Reference

  • Antimicrob Agents Chemother. 2000 Sep;44(9):2442–2451.

• • Author

  • Krugliak M, Feder R, Zolotarev VY, Gaidukov L, Dagan A, Ginsburg H, Mor A.