General Information

    • DRAMP ID

    • DRAMP38961

    • Peptide Name

    • Dermaseptin-S4(1-12)

    • Source

    • Phyllomedusa sauvagei (Sauvage's leaf frog)

    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.

    • Gene

    • Not found

    • Sequence

    • ALWMTLLKKVLK

    • Sequence Length

    • 12

    • Protein Existence

    • protein level

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antibacterial，Anti-Gram-,Antiprotozoal

    • Target Organism

      • [Ref.10952593] protozoon: P. falciparum-infected RBC(IC50=100μM);ring stage of P. falciparum(IC50~5.0μM)
      • Gram-negative bacteria:
        Target OrganismActivity
        E. coli50μM<IC50<100μM

    • Hemolytic Activity

      • [Ref.10952593]LC50=100μM against on human red blood cells

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

Physicochemical Information

    • Formula

    • C70H122N16O14S1

    • Absent Amino Acids

    • Cys,Asp,Glu,Phe,G

    • Common Amino Acids

    • Ala,Lys,L

    • Mass

    • 1443.88

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +3

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.008

    • Aliphatic Index

    • 162.5

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 3.81

    • Polar Residues

    • 1

DRAMP38961

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Antimalarial activities of dermaseptin S4 derivatives.

    • Reference

    • Antimicrob Agents Chemother. 2000 Sep;44(9):2442–2451.

    • Author

    • Krugliak M, Feder R, Zolotarev VY, Gaidukov L, Dagan A, Ginsburg H, Mor A.