• • DRAMP ID

  • DRAMP38965

• • Peptide Name

  • Dermaseptin K4–S4(1–15)a

• • Source

  • synthetic

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • ALWKTLLKKVLKAAA

• • Sequence Length

  • 15

• • UniProt Entry

  • Notfound

• • Protein Existence

  • protein level

• • SMILES

  • Not available

• • Biological Activity

  • Antimicrobial,Antibacterial，Anti-Gram-,Antiprotozoal

• • Target Organism

  • • [Ref.10952593] protozoon: P. falciparum-infected RBC(1μM<IC50<5μM);ring stage of P. falciparum(IC50~1.0μM)
    • Gram-negative bacteria:

      Target Organism	Activity
      E. coli	IC50<1.0μM

• • Hemolytic Activity

  • • [Ref.10952593]10μM

• • Cytotoxicity

  • • Not found

• • Binding Target

  • plasma membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Not found

• • Stereochemistry

  • L

• • Structure

• • Structure Description

• • PDB ID

  • Notfound

• Predicted Structure

• Please click DRAMP38965_predicted_structure.pdb to download.

DRAMP38965

• ·Literature 1

• • Title

  • Antimalarial activities of dermaseptin S4 derivatives.

• • Pubmed ID

  • 10952593

• • Reference

  • Antimicrob Agents Chemother. 2000 Sep;44(9):2442–2451.

• • Author

  • Krugliak M, Feder R, Zolotarev VY, Gaidukov L, Dagan A, Ginsburg H, Mor A.