General Information

    • DRAMP ID

    • DRAMP38995

    • Peptide Name

    • CLIP

    • Source

    • synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LPKPPKPVSKMRMATPLLMQALPM

    • Sequence Length

    • 24

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antiprotozoal

    • Target Organism

      • [Ref.31862270]protozoon: L. major promastigote(10% inhibition at 500μg/ml)

    • Hemolytic Activity

      • [Ref.31862270]no hemolytic activity was found
      • [Ref.30811391]non- hemolytic activity

    • Cytotoxicity

      • [Ref.31862270]no cytotoxicity targeting on THP1cells.

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP38995.

Physicochemical Information

    • Formula

    • C121H211N31O28S4

    • Absent Amino Acids

    • Cys,Asp,Glu,Phe,G

    • Common Amino Acids

    • Ala,Lys,L

    • Mass

    • 2676.42

    • PI

    • 11.26

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +4

    • Boman Index

    • 0

    • Hydrophobicity

    • -0

    • Aliphatic Index

    • 85.42

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP38995

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Comparative study of different forms of Jellein antimicrobial peptide on Leishmania parasite

    • Reference

    • Exp Parasitol. 2020 Feb:209:107823.

    • Author

    • Zahedifard F, Lee H, No JH, Salimi M, Seyed N, Asoodeh A, Rafati S.
  • ·Literature 2

    • Title

    • Anti-leishmanial activity of Brevinin 2R and its Lauric acid conjugate type against L. major: In vitro mechanism of actions and in vivo treatment potentials.

    • Reference

    • PLoS Negl Trop Dis. 2019 Feb 27;13(2):e0007217.

    • Author

    • Zahedifard F, Lee H, No JH, Salimi M, Seyed N, Asoodeh A, Rafati S.