General Information

    • DRAMP ID

    • DRAMP39028

    • Peptide Name

    • LFampin265–284

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the transferrin family.

    • Gene

    • LTF

    • Sequence

    • DLIWKLLSKAQEKFGKNKSR

    • Sequence Length

    • 20

    • Protein Existence

    • protein level

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antiprotozoal

    • Target Organism

      • [Ref.28165283]protozoon: Giardia intestinalis trophozoites(95% inhibition at 80μmol/L)
      • [Ref.20140481]protozoon: Entamoeba histolytica trophozoite(50μM caused approximately 50% of mortality)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasmalemma,endomembrane and cytoskeleton

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

Physicochemical Information

    • Formula

    • C109H181N31O29

    • Absent Amino Acids

    • Cys,His,Met,Pro,T

    • Common Amino Acids

    • Ala,Asp,G

    • Mass

    • 2389.79

    • PI

    • 10.17

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.01

    • Aliphatic Index

    • 83

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 2.3

    • Polar Residues

    • 4

DRAMP39028

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Parasiticidal effect of synthetic bovine lactoferrin peptides on the enteric parasite Giardia intestinalis.

    • Reference

    • Biochem Cell Biol. 2017 Feb;95(1):82-90.

    • Author

    • Aguilar-Diaz H, Canizalez-Roman A, Nepomuceno-Mejia T, Gallardo-Vera F, Hornelas-Orozco Y, Nazmi K, Bolscher JG, Carrero JC, Leon-Sicairos C, Leon-Sicairos N.
  • ·Literature 2

    • Title

    • Microbicidal effect of the lactoferrin peptides lactoferricin17-30, lactoferrampin265-284, and lactoferrin chimera on the parasite Entamoeba histolytica.

    • Reference

    • Biometals. 2010 Jun;23(3):563-8.

    • Author

    • López-Soto F, León-Sicairos N, Nazmi K, Bolscher JG, de la Garza M.