General Information

    • DRAMP ID

    • DRAMP39049

    • Peptide Name

    • Of-Pis1

    • Source

    • Oplegnathus fasciatus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLGMLLHGVGHAIHGLI

    • Sequence Length

    • 17

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-,Antifungal,Antiprotozoal

    • Target Organism

      • [Ref.18929530]protozoon: Miamiensis avidus(MIC=0.4µM,IC50<0.4µM)
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli(MIC=45µM,IC50<45µM);Edwardsiella tarda(MIC>90µM,IC50=45µM);Vibrio tapetisMIC=22.5µM,IC50=5.6µM
      • Gram-positive bacteria:
        Target OrganismActivity
        Streptococcus iniaeMIC=45µM,IC50=22.5µM
      • Fungi:
        Target OrganismActivity
        Candida albicans(MIC=22.5µM,IC50=2.8µM);Saccharomyces cerevisiaeMIC=11.25µM,IC50=1.4µM

    • Hemolytic Activity

      • [Ref.18929530]at the concentration of 56.02 µM, pOf-Pis1 lysed less than 3.25% of erythrocytes

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

Physicochemical Information

    • Formula

    • C84H133N23O18S1

    • Absent Amino Acids

    • Cys,Asp,Glu,Lys,A

    • Common Amino Acids

    • Ala,Phe,G

    • Mass

    • 1785.16

    • PI

    • 7.02

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • 0

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.014

    • Aliphatic Index

    • 160.59

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP39049

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Molecular, genomic, and expressional delineation of a piscidin from rock bream (Oplegnathus fasciatus) with evidence for the potent antimicrobial activities of Of-Pis1 peptide.

    • Reference

    • Fish Shellfish Immunol. 2016 Jan;48:154-68.

    • Author

    • Umasuthan N, Mothishri MS, Thulasitha WS, Nam BH, Lee J.