General Information
-
DRAMP ID
- DRAMP39050
-
Peptide Name
- So-pis
-
Source
- Sciaenops ocellatus
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- IWGLIAHGVAHVGSLIHGLVNG
-
Sequence Length
- 22
-
UniProt Entry
- Notfound
-
Protein Existence
- Not found
-
SMILES
- Not available
Activity Information
-
Biological Activity
- Antimicrobial, Antiprotozoal
-
Target Organism
-
- [Ref.34781186]protozoon: C. irritants trophonts(kill 20 % C.irritans trophonts at a concentration of 12 μM in an hour and 83 % trophonts at a concentration of 24 μM within half an hour. 48 μM and 96 μM of So-pis could kill all trophonts in 30 min and 15 min, respectively.)
-
Hemolytic Activity
-
- [Ref.34781186]not haemolytic in red drum erythrocytes at a concentration of less than 48 μM. Moreover, less than 10 % of erythrocytes were lysed at the concentration of 48 μM
-
Cytotoxicity
-
- Not found
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Not found
-
Stereochemistry
- L
-
Structure
-
Structure Description
-
PDB ID
- Notfound
-
Predicted Structure
- There is no predicted structure for DRAMP39050.
Physicochemical Information
-
Formula
- C103H162N30O25
Absent Amino Acids
- Cys,Asp,Glu,Phe,L
Common Amino Acids
- Ala,Gly,H
Mass
- 2220.57
PI
- 7.02
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- 0
-
Boman Index
- 0
Hydrophobicity
- 0.011
Aliphatic Index
- 155
Half Life
-
- Mammalian:20 hours
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 2.48
Polar Residues
- 2
DRAMP39050
Comments Information
Literature Information
- ·Literature 1
-
Title
- Molecular characterisation and biological activity of an antiparasitic peptide from Sciaenops ocellatus and its immune response to Cryptocaryon irritans.
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Pubmed ID
- 34781186
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Reference
- Mol Immunol. 2022 Jan;141:1-12.
-
Author
- Jin Y, Mao Y, Niu SF, Pan Y, Zheng WH, Wang J.
