• • DRAMP ID

  • DRAMP39074

• • Peptide Name

  • XPF-St5

• • Source

  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

• • Family

  • not found

• • Gene

  • not found

• • Sequence

  • GWLPTFGKILRKAMQLGPKLIQPI

• • Sequence Length

  • 24

• • UniProt Entry

  • A0A8J1JR09(38-62)

• • Protein Existence

  • predicted

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)[C@H](C)CC)[C@H](C)CC)C(=O)O

• • Biological Activity

  • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-,Antifungal,Antiprotozoal

• • Target Organism

  • • [Ref.23935531]protozoon: Trypanosoma brucei (LC₉₅=2–4 μM)
    • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus (MIC=8–16 μM); Micrococcus luteus (MIC=0.5 μM);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli (MIC=2–4 μM); Pseudomonas aeruginosa (MIC=16 μM);	-

    • Fungi:

      Target Organism	Activity
      Saccharomyces cerevisiae	MIC=8 μM

• • Hemolytic Activity

  • • [Ref.23935531]HC₅₀=64 μM

• • Cytotoxicity

  • • [Ref.23935531]IC₅₀=8 μM on mouse T-lymphocytes

• • Binding Target

  • membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • PDB ID

  • notfound

• Predicted Structure

• Please click DRAMP39074_predicted_structure.pdb to download.

DRAMP39074

• ·Literature 1

• • Title

  • Origin and functional diversification of an amphibian defense peptide arsenal

• • Pubmed ID

  • 23935531

• • Reference

  • PLoS Genet. 2013;9(8):e1003662

• • Author

  • Roelants K, Fry BG, Ye L, Stijlemans B, Brys L, Kok P, Clynen E, Schoofs L, Cornelis P, Bossuyt F