• • DRAMP ID

  • DRAMP39076

• • Peptide Name

  • XPF-St7

• • Source

  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

• • Family

  • not found

• • Gene

  • pgq

• • Sequence

  • GLLSNVAGLLKQFAKGGVNAVLNPK

• • Sequence Length

  • 25

• • UniProt Entry

  • A0A6I8R842(82-10)

• • Protein Existence

  • predicted

• • SMILES

  • CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)C(C)C

• • Biological Activity

  • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-,Antifungal,Antiprotozoal

• • Target Organism

  • • [Ref.23935531]protozoon: Trypanosoma brucei (LC₉₅=1–8 μM)
    • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus (MIC=128 μM); Micrococcus luteus (MIC=0.5 μM);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli (MIC=1 μM); Pseudomonas aeruginosa (MIC=4 μM);	-

    • Fungi:

      Target Organism	Activity
      Saccharomyces cerevisiae	MIC=8 μM

• • Hemolytic Activity

  • • [Ref.23935531]HC50 : 64 μM

• • Cytotoxicity

  • • [Ref.23935531]IC₅₀=16 μM on mouse T-lymphocytes

• • Binding Target

  • membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • PDB ID

  • notfound

• Predicted Structure

• Please click DRAMP39076_predicted_structure.pdb to download.

DRAMP39076

• ·Literature 1

• • Title

  • Origin and functional diversification of an amphibian defense peptide arsenal

• • Pubmed ID

  • 23935531

• • Reference

  • PLoS Genet. 2013;9(8):e1003662

• • Author

  • Roelants K, Fry BG, Ye L, Stijlemans B, Brys L, Kok P, Clynen E, Schoofs L, Cornelis P, Bossuyt F