• • DRAMP ID

  • DRAMP39077

• • Peptide Name

  • XPF-St8

• • Source

  • Eumenes micado (Potter wasp)

• • Family

  • Belongs to the MCD family. Mastoparan subfamily

• • Gene

  • not found

• • Sequence

  • GFMSKVANFAKKFAKGGVNAIMNQK

• • Sequence Length

  • 25

• • UniProt Entry

  • P0DX31

• • Protein Existence

  • protein level

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(C)C)C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O

• • Biological Activity

  • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-,Antifungal,Antiprotozoal

• • Target Organism

  • • [Ref.30857348]protozoon: Leishmania major(IC50=36 µM)
    • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus ATCC 6538(MIC=34 μM); Staphylococcus aureus ATCC 25923(MIC=7 μM); Staphylococcus saprophyticus (CS)(MIC=3 μM); Staphylococcus epidermis (CS)(MIC=34 μM); Bacillus subtilis CCT 2471(MIC=68 μM);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli ATCC 25922(MIC=7 μM); Escherichia coli CCT 1371(MIC=17 μM); Escherichia cloacae ATCC 23355	MIC=17 μM

• • Hemolytic Activity

  • • [Ref.30857348]no significant hemolytic activity at the concentration of 10^-4M

• • Cytotoxicity

  • • [Ref.30857348]Degranulation activity at concentration >30um

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • PDB ID

  • notfound

• Predicted Structure

• Please click DRAMP39077_predicted_structure.pdb to download.

DRAMP39077

• ·Literature 1

• • Title

  • New Mastoparan Peptides in the Venom of the Solitary Eumenine Wasp Eumenes micado

• • Pubmed ID

  • 30857348

• • Reference

  • Toxins (Basel). 2019 Mar 10;11(3):155

• • Author

  • Konno K, Kazuma K, Rangel M, Stolarz-de-Oliveira J, Fontana R, Kawano M, Fuchino H, Hide I, Yasuhara T, Nakata Y