General Information

    • DRAMP ID

    • DRAMP39078

    • Peptide Name

    • Mastoparan-EM1

    • Source

    • Eumenes micado (Potter wasp)

    • Family

    • Belongs to the MCD family. Mastoparan subfamily

    • Gene

    • not found

    • Sequence

    • LKLMGIVKKVLGAL

    • Sequence Length

    • 14

    • Protein Existence

    • protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial,Antibacterial，Anti-Gram+，Anti-Gram-,Antiprotozoal

    • Target Organism

      • [Ref.30857348]protozoon: Leishmania major(IC50=36 µM);
      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureus ATCC 6538(MIC=17 μM); Staphylococcus aureus ATCC 25923(MIC=3 μM); Staphylococcus saprophyticus (CS)(MIC=3 μM); Staphylococcus epidermis (CS)(MIC=34 μM); Bacillus subtilis CCT 2471(MIC=68 μM);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC 25922(MIC=3 μM); Escherichia coli CCT 1371(MIC=34 μM); Escherichia cloacae ATCC 23355(MIC=34 μM); Pseudomonas aeruginosa ATCC 15442MIC=34 μM

    • Hemolytic Activity

      • [Ref.30857348]no significant hemolytic activity at the concentration of 10^-4M

    • Cytotoxicity

      • [Ref.30857348]Degranulation activity at concentration >30um

    • Binding Target

    • membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Predicted Structure

Physicochemical Information

    • Formula

    • C71H133N17O15

    • Absent Amino Acids

    • Cys,Asp,Glu,Phe,H

    • Common Amino Acids

    • Ala,Gly,I

    • Mass

    • 1464.92

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.016

    • Aliphatic Index

    • 215.71

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP39078

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • New Mastoparan Peptides in the Venom of the Solitary Eumenine Wasp Eumenes micado

    • Reference

    • Toxins (Basel). 2019 Mar 10;11(3):155

    • Author

    • Konno K, Kazuma K, Rangel M, Stolarz-de-Oliveira J, Fontana R, Kawano M, Fuchino H, Hide I, Yasuhara T, Nakata Y