• • DRAMP ID

  • DRAMP39079

• • Peptide Name

  • Mastoparan-EM2

• • Source

  • synthetic

• • Family

  • not found

• • Gene

  • not found

• • Sequence

  • LKLLGIVKKVLGAI

• • Sequence Length

  • 14

• • UniProt Entry

  • notfound

• • Protein Existence

  • not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)[C@H](C)CC)C(C)C)C(C)C)C(N)=O

• • Biological Activity

  • Antimicrobial,Antibacterial，Anti-Gram+，Anti-Gram-,Antiprotozoal

• • Target Organism

  • • [Ref.19752273]protozoon: Plasmodium falciparum Dd2 strain (IC₅₀=4.5±0.6 μM); Plasmodium falciparum Δpfpm1 strain (IC₅₀=3.7±0.2 μM); Plasmodium falciparum Δpfpm2 strain (IC₅₀=3.0±0.2 μM,); Plasmodium falciparum Δpfpm3 strain (IC₅₀=2.8±0.1 μM, ); Plasmodium falciparum Δpfpm4 strain (IC₅₀=3.0±0.1 μM, ); Plasmodium falciparum GC03 strain (IC₅₀=3.2±0.2 μM, P<0.01); Plasmodium falciparum 3D7 strain (IC₅₀=3.4±0.2 μM); Plasmodium falciparum Δ3pfpm strain (IC₅₀=3.0±0.2 μM); Plasmodium falciparum Δ4pfpm strain (IC₅₀=2.1±0.2 μM)

• • Hemolytic Activity

  • • not found

• • Cytotoxicity

  • • not found

• • Binding Target

  • membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • trans-Epoxysuccinylation

• • C-terminal Modification

  • 4-guanidinobutyl-amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • PDB ID

  • notfound

• Predicted Structure

• Please click DRAMP39079_predicted_structure.pdb to download.

DRAMP39079

• ·Literature 1

• • Title

  • Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors

• • Pubmed ID

  • 19752273

• • Reference

  • Antimicrob Agents Chemother. 2009 Dec;53(12):4968-78

• • Author

  • Moura PA, Dame JB, Fidock DA.