• • DRAMP ID

  • DRAMP39134

• • Peptide Name

  • Dermaseptin K4-S4(1–10)a

• • Source

  • Agalychnis dacnicolor (Giant Mexican leaf frog) (Pachymedusa dacnicolor)

• • Family

  • Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily

• • Gene

  • not found

• • Sequence

  • ALWKTLLKKV

• • Sequence Length

  • 10

• • UniProt Entry

  • O93452(45-54)

• • Protein Existence

  • homology

• • SMILES

  • CC(C)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O

• • Biological Activity

  • Antimicrobial,Antibacterial，Anti-Gram+，Anti-Gram-,Antifungal,Antiprotozoal

• • Target Organism

  • • [Ref.11847217]protozoon: Leishmania major(LC50>50 µM)
    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli	MIC=50±10 µM

    • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus	MIC>50 µM

    • Fungi:

      Target Organism	Activity
      Cryptococcus neoformans	MIC=30±5 µM

• • Hemolytic Activity

  • • [Ref.11847217]LC50>50 µM on RBC

• • Cytotoxicity

  • • not found

• • Binding Target

  • membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • PDB ID

  • notfound

• Predicted Structure

• Please click DRAMP39134_predicted_structure.pdb to download.

DRAMP39134

• ·Literature 1

• • Title

  • Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives

• • Pubmed ID

  • 11847217

• • Reference

  • J Biol Chem. 2002 May 10;277(19):16941-51

• • Author

  • Kustanovich I, Shalev DE, Mikhlin M, Gaidukov L, Mor A