• • DRAMP ID

  • DRAMP39215

• • Peptide Name

  • Dermaseptin-S1 (1-15) code 3

• • Source

  • Phyllomedusa sauvagei (Sauvage's leaf frog)

• • Family

  • Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.

• • Gene

  • not found

• • Sequence

  • ALWKTMLKKLGTMAL

• • Sequence Length

  • 15

• • UniProt Entry

  • P24302(46-60)

• • Protein Existence

  • protein level

• • SMILES

  • CSCC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O

• • Biological Activity

  • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-,Antifungal,Antiprotozoal

• • Target Organism

  • • [Ref.18676150]protozoon: Leishmania major (MIC=22.8 μM, LC₅₀=8.7 μM)
    • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus (MIC=11.5 μM);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli (MIC=2.9 μM);	-

    • Fungi:

      Target Organism	Activity
      Candida albicans	MIC=23.7 μM

• • Hemolytic Activity

  • • [Ref.18676150]HD₅₀>100 μM

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • PDB ID

  • notfound

• Predicted Structure

• Please click DRAMP39215_predicted_structure.pdb to download.

DRAMP39215

• ·Literature 1

• • Title

  • Synthesis and antimicrobial activity of dermaseptin S1 analogues

• • Pubmed ID

  • 18676150

• • Reference

  • Bioorg Med Chem. 2008 Sep 1;16(17):8205-9

• • Author

  • Savoia D, Guerrini R, Marzola E, Salvadori S