General Information

    • DRAMP ID

    • DRAMP39270

    • Peptide Name

    • An-cecB-1

    • Source

    • Anopheles gambiae (African malaria mosquito)

    • Family

    • Belongs to the cecropin family.

    • Gene

    • CecB

    • Sequence

    • APRWKFGKRLEKLGRNVF

    • Sequence Length

    • 17

    • Protein Existence

    • protein level

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-,Antiprotozoal

    • Target Organism

      • [Ref.38874346]protozoon: P. falciparum 3D7 strain(IC50=68.63μM)
      • Gram-positive bacteria:
        Target OrganismActivity
        S. aureus(MIC>200μM;IC50>200μM);B. subtilisMIC=25μM;IC50=18.94μM
      • Gram-negative bacteria:
        Target OrganismActivity
        E. coliMIC=25μM;IC50=12.7μM

    • Hemolytic Activity

      • [Ref.38874346]Had no hemolysis effect on erythrocytes

    • Cytotoxicity

      • [Ref.38874346]No toxicity to HEK293T cells at various drug concentrations

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Predicted Structure

    • There is no predicted structure for DRAMP39270.

Physicochemical Information

    • Formula

    • C103H164N32O22

    • Absent Amino Acids

    • Cys,Asp,His,Ile,M

    • Common Amino Acids

    • Ala,Glu,P

    • Mass

    • 2202.61

    • PI

    • 11.73

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +5

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.009

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 2.5

    • Polar Residues

    • 1

DRAMP39270

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes.

    • Reference

    • Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0031124.

    • Author

    • Lou J, Zhang D, Wu J, Zhu G, Zhang M, Tang J, Fang Y, He X, Cao J.